Just as I thought I was getting comfortable with Fedora there was a serious system crash. I had Firefox, Deluge, and Pidgin open at the time, which is nothing intensive for a powerful system like this but the screen froze and I found I couldn't revive the system.
I tried CTRL+ALT+F2 to switch run levels and perhaps recover things from a terminal but the system was completely unresponsive. I couldn't even reset the system with CTRL+ALT+DEL and I had to power it off manually.
When I tried to reboot the system it would get to a certain point and then the whole screen would just flash on and off with no sign of stopping. I tried a few times to make it work and even tried recovering the system with the Fedora DVD to no avail.
In the end I had no option but to completely reinstall from scratch. I'm not sure what caused this but I suspect it was the Nvidia driver I tried to install. I rebuilt the system up the same point as before bit left the video drivers alone, hoping this would prevent a similar crash.