CIO.com: What can you do when you know you could handle a job, but you don't meet all the requirements listed in the posting? First, double-check to make sure you really would be a good fit for the job. Next, find an ally who can go to bat for you with the hiring manager. Be open about the gaps in your experience and offer ways to make hiring you less risky. Emphasize the benefits the company will gain by hiring you, and above all, be honest.