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Works with: All email clients
Pros: Blacklist, whitelist, regular expression matching; image spam filtering; several other filtering options.
Cons: No Bayesian filter; no IMAP support; no direct integration with email clients; cluttered interface; poor documentation.
Em@ilCRX has a peculiar interface (with, for example, unlabeled checkboxes in odd places and a seemingly endless proliferation of windows). It works only with POP accounts, and functions as a proxy: it checks your email, and then your email client connects to Em@ilCRX, from where it downloads the filtered messages.
You must always have Em@ilCRX running in the background in order to check your mail, and you must also switch to it to correct any false positives or false negatives. Unfortunately, the setup process for both Em@ilCRX and your email client is odd, complex, and poorly documented. If you can get past the setup and UI, the programs functionality is comparatively solid, and includes options to record spam and phishing attempts in a central database and to report spammers to their ISPs (though I think the latter is less useful than commonly believed).